The WAVE System Model 4500 is one of the most sensitive and accurate technologies for separation and sequence variant analysis of nucleic acid fragments. As a proven technology, the WAVE System is used by many of the world.s leading medical centers. The WAVE 4500 System is fully automated, from sample collection to results analysis. Navigator. Software is included and creates the fragment specific methods, controls the instrument and analyzes your results. Fragment separation is achieved by the patented DNASep® Cartridge located in the system oven. The fragments pass through the system’s ultraviolet detector and absorbance is recorded over time. This information is processed by the Navigator Software suite. It records the results in the form of chromatograms that can be further analyzed and filed by Navigator. Screening by WAVE system reduces the sequencing costs and increases the speed of variant analysis in a large samples or gene with many exons, eg BRCA1 & 2, MSH1 & MLH2. The system can process 2 x 96 well sample plate unattended for Mutational Analysis and the average run time is < 5 mins for each sample
The Fragment collector FCW 200 connected to the WAVE 4500 – can collect the separated fragment, by clicking the peak of your interest for further processing such as sequence analysis.
The WAVE System can operate under three modes based on the temperature in the oven, allowing multiple applications with one system. Navigator Software provides a platform for simple method development for each application as well as substantial flexibility for novel procedures